to receive support from dedicated Research Data Editors London, 13 February 2019 A new pilot project by Springer Nature and the Breast Cancer Research Foundation (BCRF) enables researchers to make their research datasets accessible alongside their published articles.
From February 2019, all authors whose manuscripts are accepted for publication by will be reviewed by a Research Data Editor who is responsible for cataloguing, describing and sharing the datasets that accompany the research paper.
Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma.
Nonsense mediated decay (NMD) of m RNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Background: Infections of teeth are highly prevalent, often leading to tooth extractions.
This has been developed by advances in technologies and approaches including next generation sequencing, mass spectrometry, circulating tumour cells, and cell-free DNA.
The discovery and use of specific prognostic and predictive biomarkers have enabled the application of targeted precision therapies to specific molecular subgroups of patients likely to gain benefit.We encourage submissions of original research findings regarding new biomarkers for breast cancer and new approaches for their detection and validation.The markers may include, but are not limited to, genomic, transcriptomic, epigenetic, and proteomic.The dedicated editors, who work as part of Springer Nature’s Research Data Support services team, will help authors draft detailed descriptions of the datasets supporting their articles and deposit datasets in a newly-created journal data repository.The editors also give advice on de-identifying data about human research participants, and help authors write detailed data availability statements.Attendees of such a workshop in October 2018 said that they would be much more likely to share their data after having received this professional training’s Editor-in-Chief said: “The provision of this service for all of our authors is in part a response to the calls for broader data sharing that have been gathering pace in the cancer research community.“Margaret Flowers, Director, Scientific Communications and Grants, BCRF, said: “As part of our commitment to drive advances in cancer research, we want to encourage our BCRF-funded researchers and other investigators to share their data with the wider research community, and to enable others to build on the findings and knowledge gained from our funded projects.BCRF’s collaboration with Springer Nature enables us to provide the practical support and professional development to researchers that we think is essential.”Grace Baynes, Vice-President, Research Data & New Product Development at Springer Nature, said: “Not all oncology research data can be made openly available, but it can all be made easier to find and access.Indeed, the development in tandem of companion-diagnostics alongside new drugs is often essential to obtain licensing approval from regulatory bodies.Additionally, the use of biomarkers can allow for the identification of patients with a favorable prognosis who can safely be spared from unnecessary overtreatment.Within breast cancer, recent biomarker discovery efforts have led to the identification and development of several prognostic and predictive biomarkers including multigene signatures.Some are now commercially available and approved for clinical use while others remain to be clinically validated.